Pharmacokinetic study of metopimazine by oral route in children
Identifieur interne : 000166 ( Main/Exploration ); précédent : 000165; suivant : 000167Pharmacokinetic study of metopimazine by oral route in children
Auteurs : Eric Mallet [France] ; Frederic Bounoure [France] ; Mohamed Skiba [France] ; Elodie Saussereau [France] ; Jean-Pierre Goullé [France] ; Mireille Castanet [France]Source :
- Pharmacology Research & Perspectives [ 2052-1707 ] ; 2015.
Abstract
Metopimazine (MPZ) is an antiemetic considered as a currently used drug. In France, it has become the leading antiemetic mediator due to its good tolerance, however, its pharmacokinetics has never previously been studied in children. MPZ was administered by oral route to 8 children with a single dose of 0.33 mg/kg during an endocrine exploration using stimuli well known for its adverse emetic effects. We used biological remnants from sera following an hGH test in order to obtain the MPZ pharmacokinetics. Plasmatic concentrations of MPZ and the active acid metabolite AMPZ, were quantified by HPLC-MS/MS during a 270 min test period. MPZ is quickly absorbed with a median
Url:
DOI: 10.1002/prp2.130
PubMed: 26171218
PubMed Central: 4492748
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000013
- to stream Pmc, to step Curation: 000013
- to stream Pmc, to step Checkpoint: 000019
- to stream PubMed, to step Corpus: 000089
- to stream PubMed, to step Curation: 000089
- to stream PubMed, to step Checkpoint: 000089
- to stream Ncbi, to step Merge: 000489
- to stream Ncbi, to step Curation: 000489
- to stream Ncbi, to step Checkpoint: 000489
- to stream Main, to step Merge: 000164
- to stream Main, to step Curation: 000166
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacokinetic study of metopimazine by oral route in children</title><author><name sortKey="Mallet, Eric" sort="Mallet, Eric" uniqKey="Mallet E" first="Eric" last="Mallet">Eric Mallet</name><affiliation wicri:level="3"><nlm:aff id="au1"><institution>CIC INSERM 204, Department of Pediatrics, Rouen University Hospital</institution><addr-line>Charles Nicolle, 76031, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Charles Nicolle, 76031, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Bounoure, Frederic" sort="Bounoure, Frederic" uniqKey="Bounoure F" first="Frederic" last="Bounoure">Frederic Bounoure</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Pharmaceutics Laboratory (UMR CNRS 5007), Faculty of Medicine and Pharmacy, Rouen University</institution><addr-line>76183, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>76183, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Skiba, Mohamed" sort="Skiba, Mohamed" uniqKey="Skiba M" first="Mohamed" last="Skiba">Mohamed Skiba</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Pharmaceutics Laboratory (UMR CNRS 5007), Faculty of Medicine and Pharmacy, Rouen University</institution><addr-line>76183, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>76183, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe Hospitalier du Havre</institution><addr-line>BP 24, 76083, Le Havre, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>BP 24, 76083, Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe Hospitalier du Havre</institution><addr-line>BP 24, 76083, Le Havre, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>BP 24, 76083, Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Castanet, Mireille" sort="Castanet, Mireille" uniqKey="Castanet M" first="Mireille" last="Castanet">Mireille Castanet</name><affiliation wicri:level="3"><nlm:aff id="au1"><institution>CIC INSERM 204, Department of Pediatrics, Rouen University Hospital</institution><addr-line>Charles Nicolle, 76031, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Charles Nicolle, 76031, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26171218</idno><idno type="pmc">4492748</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492748</idno><idno type="RBID">PMC:4492748</idno><idno type="doi">10.1002/prp2.130</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000013</idno><idno type="wicri:Area/Pmc/Curation">000013</idno><idno type="wicri:Area/Pmc/Checkpoint">000019</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000089</idno><idno type="wicri:Area/PubMed/Curation">000089</idno><idno type="wicri:Area/PubMed/Checkpoint">000089</idno><idno type="wicri:Area/Ncbi/Merge">000489</idno><idno type="wicri:Area/Ncbi/Curation">000489</idno><idno type="wicri:Area/Ncbi/Checkpoint">000489</idno><idno type="wicri:doubleKey">2052-1707:2015:Mallet E:pharmacokinetic:study:of</idno><idno type="wicri:Area/Main/Merge">000164</idno><idno type="wicri:Area/Main/Curation">000166</idno><idno type="wicri:Area/Main/Exploration">000166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pharmacokinetic study of metopimazine by oral route in children</title><author><name sortKey="Mallet, Eric" sort="Mallet, Eric" uniqKey="Mallet E" first="Eric" last="Mallet">Eric Mallet</name><affiliation wicri:level="3"><nlm:aff id="au1"><institution>CIC INSERM 204, Department of Pediatrics, Rouen University Hospital</institution><addr-line>Charles Nicolle, 76031, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Charles Nicolle, 76031, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Bounoure, Frederic" sort="Bounoure, Frederic" uniqKey="Bounoure F" first="Frederic" last="Bounoure">Frederic Bounoure</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Pharmaceutics Laboratory (UMR CNRS 5007), Faculty of Medicine and Pharmacy, Rouen University</institution><addr-line>76183, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>76183, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Skiba, Mohamed" sort="Skiba, Mohamed" uniqKey="Skiba M" first="Mohamed" last="Skiba">Mohamed Skiba</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Pharmaceutics Laboratory (UMR CNRS 5007), Faculty of Medicine and Pharmacy, Rouen University</institution><addr-line>76183, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>76183, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe Hospitalier du Havre</institution><addr-line>BP 24, 76083, Le Havre, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>BP 24, 76083, Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe Hospitalier du Havre</institution><addr-line>BP 24, 76083, Le Havre, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>BP 24, 76083, Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Castanet, Mireille" sort="Castanet, Mireille" uniqKey="Castanet M" first="Mireille" last="Castanet">Mireille Castanet</name><affiliation wicri:level="3"><nlm:aff id="au1"><institution>CIC INSERM 204, Department of Pediatrics, Rouen University Hospital</institution><addr-line>Charles Nicolle, 76031, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Charles Nicolle, 76031, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author></analytic><series><title level="j">Pharmacology Research & Perspectives</title><idno type="ISSN">2052-1707</idno><idno type="eISSN">2052-1707</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Metopimazine (MPZ) is an antiemetic considered as a currently used drug. In France, it has become the leading antiemetic mediator due to its good tolerance, however, its pharmacokinetics has never previously been studied in children. MPZ was administered by oral route to 8 children with a single dose of 0.33 mg/kg during an endocrine exploration using stimuli well known for its adverse emetic effects. We used biological remnants from sera following an hGH test in order to obtain the MPZ pharmacokinetics. Plasmatic concentrations of MPZ and the active acid metabolite AMPZ, were quantified by HPLC-MS/MS during a 270 min test period. MPZ is quickly absorbed with a median <italic>C</italic><sub>max</sub> of 17.2 ng/mL at one hour and its half-life is 2.18 h. The plasmatic concentrations of AMPZ were higher than MPZ with a median <italic>C</italic><sub>max</sub> of 76.3 ng/mL, a <italic>T</italic><sub>max</sub> to 150 min and its concentration was approximately maintained at 50 ng/mL from 1 to 4 h. The plasmatic concentrations in children are similar to those observed in adults. No adverse effects, nausea or vomiting occurred during the trial. Therefore, these results confirm the MPZ dosage that should be used in children under 15 kg administered as 0.33 mg/kg up to 3 times a day.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Colle, M" uniqKey="Colle M">M Colle</name></author><author><name sortKey="Battin, J" uniqKey="Battin J">J Battin</name></author><author><name sortKey="Coquelin, Jp" uniqKey="Coquelin J">JP Coquelin</name></author><author><name sortKey="Rochiccioli, P" uniqKey="Rochiccioli P">P Rochiccioli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dillman, Jr" uniqKey="Dillman J">JR Dillman</name></author><author><name sortKey="Smith, Ea" uniqKey="Smith E">EA Smith</name></author><author><name sortKey="Khalatbari, S" uniqKey="Khalatbari S">S Khalatbari</name></author><author><name sortKey="Strouse, Pj" uniqKey="Strouse P">PJ Strouse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bounoure, F" uniqKey="Bounoure F">F Bounoure</name></author><author><name sortKey="Lahiani, Skibam" uniqKey="Lahiani S">SkibaM Lahiani</name></author><author><name sortKey="Besnard, M" uniqKey="Besnard M">M Besnard</name></author><author><name sortKey="Arnaud, P" uniqKey="Arnaud P">P Arnaud</name></author><author><name sortKey="Mallet, E" uniqKey="Mallet E">E Mallet</name></author><author><name sortKey="Skiba, M" uniqKey="Skiba M">M Skiba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrstedt, J" uniqKey="Herrstedt J">J Herrstedt</name></author><author><name sortKey="J Rgensen, M" uniqKey="J Rgensen M">M Jørgensen</name></author><author><name sortKey="Angelo, Hr" uniqKey="Angelo H">HR Angelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrstedt, J" uniqKey="Herrstedt J">J Herrstedt</name></author><author><name sortKey="Hyttel, J" uniqKey="Hyttel J">J Hyttel</name></author><author><name sortKey="Pedersen, J" uniqKey="Pedersen J">J Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrstedt, J" uniqKey="Herrstedt J">J Herrstedt</name></author><author><name sortKey="J Rgensen, M" uniqKey="J Rgensen M">M Jørgensen</name></author><author><name sortKey="Angelo, Hr" uniqKey="Angelo H">HR Angelo</name></author><author><name sortKey="Rassing, Mr" uniqKey="Rassing M">MR Rassing</name></author><author><name sortKey="M Ller Sonnergaard, J" uniqKey="M Ller Sonnergaard J">J Møller- Sonnergaard</name></author><author><name sortKey="Dombernowsky, P" uniqKey="Dombernowsky P">P Dombernowsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrstedt, J" uniqKey="Herrstedt J">J Herrstedt</name></author><author><name sortKey="Sigsgaard, T" uniqKey="Sigsgaard T">T Sigsgaard</name></author><author><name sortKey="Angelo, Hr" uniqKey="Angelo H">HR Angelo</name></author><author><name sortKey="Kampmann, Jp" uniqKey="Kampmann J">JP Kampmann</name></author><author><name sortKey="Hansen, M" uniqKey="Hansen M">M Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jolliet, P" uniqKey="Jolliet P">P Jolliet</name></author><author><name sortKey="Nion, S" uniqKey="Nion S">S Nion</name></author><author><name sortKey="Allain Veyrac, G" uniqKey="Allain Veyrac G">G Allain-Veyrac</name></author><author><name sortKey="Tilloy Fenart, L" uniqKey="Tilloy Fenart L">L Tilloy-Fenart</name></author><author><name sortKey="Vanuxeem, D" uniqKey="Vanuxeem D">D Vanuxeem</name></author><author><name sortKey="Berezowski, V" uniqKey="Berezowski V">V Berezowski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li><li>Rouen</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Mallet, Eric" sort="Mallet, Eric" uniqKey="Mallet E" first="Eric" last="Mallet">Eric Mallet</name></region><name sortKey="Bounoure, Frederic" sort="Bounoure, Frederic" uniqKey="Bounoure F" first="Frederic" last="Bounoure">Frederic Bounoure</name><name sortKey="Castanet, Mireille" sort="Castanet, Mireille" uniqKey="Castanet M" first="Mireille" last="Castanet">Mireille Castanet</name><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name><name sortKey="Skiba, Mohamed" sort="Skiba, Mohamed" uniqKey="Skiba M" first="Mohamed" last="Skiba">Mohamed Skiba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000166 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000166 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4492748
|texte= Pharmacokinetic study of metopimazine by oral route in children
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26171218" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |